✨ New: Foundayo (orforglipron) just became the first GLP-1 pill with no food restrictions, FDA approved April 2026, See it here → ✨ Foundayo approved, New GLP-1 Pill See it →
What Works · What Doesn't

A simpler way to understand weight loss medications, explained by real doctors

Reviewed by licensed physicians. Updated as the research changes.

Explore Medications → View Future Meds
✓
All content reviewed by board-certified physicians before publication
Featured MedicationsMost Searched Medications
Foundayo 💊 (Pill) ⭐ Newest
Orforglipron · GLP-1 · Daily pill
Orforglipron
Avg. weight loss: 12%
›FDA Approved
Oral Wegovy 💊 (Pill)
Oral Semaglutide · GLP-1 · Daily pill
Semaglutide
Avg. weight loss: 15%
›FDA Approved
Zepbound 💉 (Injection)
Tirzepatide · Weekly injection
Tirzepatide
Avg. weight loss: 21%
›FDA Approved
Retatrutide 💉 (Injection)
Triple Agonist · In Trials
Triple Agonist
Avg. weight loss: 24%
›Coming Soon
View More →
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Medically Reviewed
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Trial Focused
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Regularly Updated
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FDA Focused
🩺 Medically Reviewed ✅ FDA Focused 🔬 Trial Focused 🔄 Regularly Updated 🏥 Board-Certified Doctors 🩺 Medically Reviewed ✅ FDA Focused 🔬 Trial Focused 🔄 Regularly Updated 🏥 Board-Certified Doctors
Most Searched Medications
Foundayo 💊 (Pill) ⭐ Newest
Orforglipron
Avg. weight loss: 12%
›FDA Approved
Oral Wegovy 💊 (Pill)
Semaglutide
Avg. weight loss: 15%
›FDA Approved
Zepbound 💉 (Injection)
Tirzepatide
Avg. weight loss: 21%
›FDA Approved
Retatrutide 💉 (Injection)
Triple Agonist
Avg. weight loss: 24%
›Coming Soon
View More →
How They Work
How Weight Loss Medications Work

Here are the basics:

At a Glance

  • GLP-1s are the most effective weight loss medications ever approved
  • Available as a daily weight loss pill or weekly injection
  • Work by signaling your brain to feel full faster
  • The top medications all use one of three ingredients: semaglutide, tirzepatide or orforglipron
  • Prescription required, consult your doctor

Most searched for medications:

💊
GLP-1 · NEW

Foundayo (Pill) ⭐

Orforglipron by Eli Lilly. The first GLP-1 pill with no food restrictions, take it any time of day. FDA approved April 2026.

Avg. Wt. Loss
12.4%
Form
💊 Pill
Frequency
Daily
Status
✅ Approved
Full breakdown →
💊
GLP-1

Oral Wegovy (Pill)

Oral semaglutide for weight loss. Same active ingredient as the Wegovy injection, now in a daily pill. Must be taken on an empty stomach.

Avg. Wt. Loss
15%
Form
💊 Pill
Frequency
Daily
Status
✅ Approved
Full breakdown →
💉
GLP-1 / GIP

Zepbound (Injection)

Tirzepatide injection by Eli Lilly. Targets two hunger hormones (GLP-1 and GIP), making it one of the most effective options available.

Avg. Wt. Loss
21%
Form
💉 Injection
Frequency
Weekly
Status
✅ Approved
Full breakdown →
💉
Phase 3

Retatrutide (Injection)

Triple agonist (GLP-1, GIP, glucagon) by Eli Lilly. Shows up to 24% weight loss in trials, potentially the most powerful yet.

Avg. Wt. Loss
24%*
Form
💉 Injection
Frequency
Weekly
Status
Phase 3
Full breakdown →
View More Medications →
Comparison
Weight Loss Pills vs. Injections: How Do They Compare?

Not sure whether pills or injections are right for you? Here's how they compare, explained in simpler terms.

Feature 💊 Pills (Oral) 💉 Injections
Ease of use ✓ Easier, just one pill daily, no needles △ Requires self-injection weekly
Avg. Weight Loss 9-16% body weight 15-21% body weight
Frequency Daily Weekly (most options)
Side effects Nausea, stomach upset Nausea, injection site reaction
FDA Status ✅ Approved ✅ Approved
Best for Those who prefer convenience Those who want strongest results
Complete Guide →
Latest
News & Articles

Articles on weight loss medications, written by physicians and reviewed for accuracy.

Do weight loss pills actually work
Explainer 6 min read

Do Weight Loss Pills Actually Work? What the Trials ShowDo Weight Loss Pills Actually Work?

GLP-1 medications work through mechanisms older pills never approached. What actually works.

Why GLP-1 pills work where older diet pills failed.

Dr. Humberto Fernandez-Miro, MD Dr. Fernandez-Miro Read →
New weight loss pills approved in 2026
News 5 min read

New Weight Loss Pills in 2026: Foundayo, Orforglipron, and BeyondNew Weight Loss Pills in 2026

Foundayo's April 2026 approval reset the field of oral options. Every major one, ranked for 2026.

Every major oral pill after Foundayo's 2026 approval.

Dr. Quoc Dang, DO Dr. Dang Read →
Are weight loss pills worth it
Guide 6 min read

Are Weight Loss Pills Worth It? Cost, Side Effects, and OutcomesAre Weight Loss Pills Worth It?

Cost, side effects, and what happens when you stop. 25 years of patient experience behind the answer.

Cost, side effects, and what happens when you stop.

Dr. Humberto Fernandez-Miro, MD Dr. Fernandez-Miro Read →
See more →
Semaglutide vs. Tirzepatide comparison chart
Explainer 7 min read

Semaglutide vs Tirzepatide

Tirzepatide wins on average. When that gap matters most.

Dr. Quoc Dang, DO Dr. Dang Read →
View More Articles →
Track what's coming
New & Future Meds 🔭New & Future Meds

From recent approvals to early-stage trials, where every major weight loss drug stands right now.

🔬 Phase 1
⚗️ Phase 2
🚀 Phase 3
✅ FDA Approval
💊 Pills
Foundayo ⭐ NEW · Out Now
Orforglipron · No food restrictions · Eli Lilly
💊 Pill · FDA Approved
✓
Phase 1
✓
Phase 2
✓
Phase 3
✓
FDA ApprovedApr 2026
Amycretin
Dual mechanism · 22% weight loss · Novo Nordisk
💊 Pill + 💉 Inj. · Phase 3
✓
Phase 1
✓
Phase 2
▶
Phase 3Started Q1 2026
FDA DecisionEst. 2029
Aleniglipron
Oral GLP-1 · One to watch in 2026 · Structure Tx
💊 Pill · Phase 2
✓
Phase 1
▶
Phase 2
Phase 32026
FDA Decision
💉 Upcoming Injections
Retatrutide
Triple Agonist · Best trial results to date · Eli Lilly
💉 Injection · Phase 3
✓
Phase 1
✓
Phase 2
▶
Phase 3
FDA DecisionEst. 2027

⚕ Pipeline timelines are estimates based on current trial data and may change. Updated regularly.

See All Future Meds →
Medical Authority
Our Medical Experts

Every article and medication page is reviewed by real doctors before publication, explained in simpler terms.

Dr. Quoc Dang, DO
Dr. Quoc Dang, DO
Medical Director · Bariatric Surgery

Bariatric surgeon specializing in GLP-1 therapy and obesity medicine.

✦ Verified Reviewer
Dr. Humberto Fernandez-Miro, MD
Dr. Humberto Fernandez-Miro, MDDr. Fernandez-Miro
Family Medicine · Clinical Research

25 years in Miami. Weight loss programs, obesity trials, family medicine.

✦ Verified Reviewer
Dr. Roynny Sanchez Gil, MD
Dr. Roynny Sanchez Gil, MDDr. Sanchez Gil
General Surgery · Endocrine Surgery

Endocrine surgeon at Halifax Health. GLP-1 and obesity specialist.

✦ Verified Reviewer
See all of our medical contributors →