Weight Loss Medications

Every FDA-approved weight loss medication in one place, medically reviewed and written to be understood by patients.

6 FDA Approved
Updated
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💊 FDA-Approved Pills Oral · Take daily
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💊
✓ FDA Approved GLP-1 · Eli Lilly

Foundayo

Orforglipron · Apr 2026

A new GLP-1 pill you can take with or without food. No fasting or timing needed.Approved April 2026, Foundayo works differently from earlier GLP-1 pills. Its unique formulation does not bind to food, meaning you can take it with or without a meal, any time that fits your routine.

Avg. Wt. Loss
12.4%
Form
💊 Daily Pill
Approved For
Weight Loss
Status
✅ Approved
Full breakdown →
💊
✓ FDA Approved GLP-1 · Novo Nordisk

Oral Wegovy

Oral Semaglutide · 2023

Same results as the Wegovy shot, in pill form. Must be taken on a completely empty stomach every morning.Novo Nordisk's daily pill delivers clinical results comparable to the Wegovy injection. Dosing is strict: taken with plain water on a completely empty stomach, at least 30 minutes before your first food or drink of the day.

Avg. Wt. Loss
15%
Form
💊 Daily Pill
Approved For
Weight Loss
Status
✅ Approved
Full breakdown →
💊
✓ FDA Approved GLP-1 · Novo Nordisk

Rybelsus

Oral Semaglutide · 2019

A diabetes pill sometimes used off-label for weight loss. Lower dose than Oral Wegovy.An oral semaglutide approved for Type 2 diabetes, also used off-label for weight loss. Lower dose than Oral Wegovy, and not the preferred choice if weight loss is your primary goal.

Avg. Wt. Loss
5-10%
Form
💊 Daily Pill
Approved For
Diabetes
Status
Off-label?This drug is FDA-approved for type 2 diabetes, not for weight loss. Using it for weight loss is considered off-label use.
Full breakdown →
💉 FDA-Approved Injections Self-inject · Weekly
💉
✓ FDA Approved GLP-1 · Novo Nordisk

Wegovy

Semaglutide Injection · 2021

The original weight loss injection. FDA approved and backed by strong clinical trials.The original blockbuster GLP-1 injection. Approved specifically for weight loss and backed by the largest GLP-1 clinical trial ever run at the time of its approval.

Avg. Wt. Loss
15%
Form
💉 Weekly inj.
Approved For
Weight Loss
Status
✅ Approved
Full breakdown →
💉
✓ FDA Approved GLP-1/GIP · Eli Lilly

Zepbound

Tirzepatide Injection · 2023

More weight loss than any other FDA approved option. Targets two hunger hormones instead of one.Zepbound targets two hunger hormones instead of one, producing more weight loss than any other FDA approved medication. In a head to head trial it outperformed Wegovy by nearly 50% more weight loss.

Avg. Wt. Loss
21%
Form
💉 Weekly inj.
Approved For
Weight Loss
Status
✅ Approved
Full breakdown →
💉
✓ FDA Approved GLP-1 · Novo Nordisk

Ozempic

Semaglutide Injection · 2017

Approved for diabetes but widely used off-label for weight loss. Same ingredient as Wegovy.FDA-approved for Type 2 diabetes, widely prescribed off-label for weight loss. Same active ingredient as Wegovy but at a lower approved dose.

Avg. Wt. Loss
10-15%
Form
💉 Weekly inj.
Approved For
Diabetes
Status
Off-label?This drug is FDA-approved for type 2 diabetes, not for weight loss. Using it for weight loss is considered off-label use.
Full breakdown →
💉
✓ FDA Approved GLP-1/GIP · Eli Lilly

Mounjaro

Tirzepatide Injection · 2022

Same molecule as Zepbound, approved for diabetes. Widely used off-label for weight loss.Same active ingredient as Zepbound (tirzepatide) but approved for Type 2 diabetes rather than weight loss. Targets two hunger hormones, producing strong results in trials.

Avg. Wt. Loss
15.7%
Form
💉 Weekly inj.
Approved For
Diabetes
Status
Off-label?This drug is FDA-approved for type 2 diabetes, not for weight loss. Using it for weight loss is considered off-label use.
Full breakdown →
💉
✓ FDA Approved GLP-1 · Novo Nordisk

Saxenda

Liraglutide Injection · 2014

The original GLP-1 weight loss injection. Daily shot with more modest results than newer options.The first GLP-1 specifically approved for weight loss in 2014. Daily injection, more modest results than newer semaglutide and tirzepatide options, but still clinically meaningful.

Avg. Wt. Loss
8%
Form
💉 Daily inj.
Approved For
Weight Loss
Status
✅ Approved
Full breakdown →
💉
✓ FDA Approved GLP-1 · Eli Lilly

Trulicity

Dulaglutide Injection · 2014

A weekly GLP-1 injection for diabetes, also used off-label for weight loss.An older weekly GLP-1 injection approved for type 2 diabetes. Well-established safety record since 2014, with more modest weight loss than newer semaglutide and tirzepatide options.

Avg. Wt. Loss
5%
Form
💉 Weekly inj.
Approved For
Diabetes
Status
Off-label?This drug is FDA-approved for type 2 diabetes, not for weight loss. Using it for weight loss is considered off-label use.
Full breakdown →
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